Chun Zhang Group

@Tianjin University





张淳 教授 天津大学化学系





Research Interest:

# Discovery and development of new reaction for bio-active molecule synthesis

# Mechanistic studies of transition metal-catalyzed organic reactions


Education and Working Experience of Chun Zhang:

1. 2017/09 to today: Professor, Department of Chemistry, Tianjin University, Tianjin, China.

2. 2014/04 to 2017/08: Postdoctoral Research Fellow, Professor Matthew S. Sigman group, Department of Chemistry, University of Utah, Salt Lake City, Utah, USA.

3. 2013/08 to 2014/01: Research Assistant, Professor Ning Jiao group, College of Pharmacy, Peking University, Beijing, China.

4. 2008/09 to 2013/07: Ph. D. Candidate, Professor Ning Jiao group, College of Pharmacy, Peking University, Beijing, China.

5. 2004/09 to 2008/07: Undergraduate student, College of Pharmacy, China Pharmaceutical University, Nanjing, China.


Some selected publications:

1. Chun Zhang, Celine B. Santiago, Jennifer M. Crawford, Matthew S. Sigman*, Enantioselective Dehydrogenative Heck Arylations of Tri-substituted Alkenes with Indoles to Construct Quaternary Stereocenters, J. Am. Chem. Soc. 2015, 137, 15668.

2. Chun Zhang, Celine B. Santiago, Lei Kou, Matthew S. Sigman*, Alkenyl Carbonyl Derivatives in Enantioselective Redox Relay Heck Reactions: Accessing α,β-Unsaturated Systems, J. Am. Chem. Soc. 2015, 137, 7290.

3. Chun Zhang, Peng feng, Ning Jiao*, Cu-Catalyzed Esterification Reaction via Aerobic Oxygenation and C–C Bond Cleavage: An Approach to α-Ketoesters, J. Am. Chem. Soc. 2013, 135, 15257.

4. Chun Zhang, Ning Jiao*, Dioxygen activation under ambient conditions: Cu-catalyzed oxidative amidation−diketonization of terminal alkynes leading to α-ketoamides, J. Am. Chem. Soc. 2010, 132, 28.

5. Chun Zhang, Zejun Xu, Liangren Zhang, Ning Jiao*, Copper-catalyzed aerobic oxidative coupling of aryl acetaldehydes with anilines leading to α-ketoamides, Angew. Chem. Int. Ed. 2011, 50, 11088.

6. Chun Zhang, Ning Jiao*, Copper-catalyzed aerobic oxidative dehydrogenative coupling of anilines leading to aromatic azo compounds using dioxygen as an oxidant, Angew. Chem. Int. Ed. 2010, 49, 6174.

7. Zejun Xu,§ Chun Zhang,§ Ning Jiao*, (§ These authors contributed equally to this work) Copper-mediated aerobic oxidative dehydrogenative annulation of aldehydes, amines and molecular oxygen for oxazoles via C-H functionalization and dioxygen activation. Angew. Chem. Int. Ed. 2012, 51, 11367.

8. Chun Zhang, Brandon Tutkowski, Ryan J. DeLuca, Leo A. Joyce, Olaf Wiest, Matthew S. Sigman*, Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters, Chem. Sci. 2017, 8, 2277.

9. Chun Zhang, Conghui Tang, Ning Jiao*, Recent advances in copper-catalyzed dehydrogenative functionalization via a single electron transfer (SET) process, Chem. Soc. Rev. 2012, 41, 3464.

10. Chun Zhang, Ning Jiao*, A Cu-catalyzed Practical Approach to α-Ketoesters under Air: an Efficient Aerobic Oxidative Dehydrogenative Coupling of Alcohols and α-Carbonyl Aldehydes, Org. Chem. Frontiers, 2014, 1, 109.

11. Chun Zhang, Liangren Zhang, Ning Jiao*, Catalyst and additive free procedure to construct benzimidazoles using air as the oxidant under room temperature. Green Chem. 2012, 14, 3273.

12. Chun Zhang, Xiaolin Zong, Liangren Zhang, Ning Jiao*, Copper-catalyzed aerobic oxidative cross-dehydrogenative coupling (CDC) of amine and α-carbonyl aldehyde: a pratical and efficient method to α-ketoamides with wide substrate scope. Org. Lett. 2012, 14, 3280.

13. Chun Zhang, Zejun Xu, Tao Shen, Guolin Wu, Liangren Zhang, Ning Jiao*, Mn-mediated aerobic oxidative C-C bond cleavage of aldehydes with dioxygen activation: a simple synthetic approach to formamide. Org. Lett. 2012, 14, 2362.

14. Chun Zhang, Liangren Zhang, Ning Jiao*, Multiple oxidative dehydrogenative functionalization of aryl acetaldehydes using molecular oxygen as oxidant leading to 2-oxo-acetamidines. Adv. Synth. Catal. 2012, 354, 1293.

15. Chun Zhang, Zejun Xu, Liangren Zhang, Ning Jiao*, Et3N-catalyzed dehydrogenative oxidation of α-unsubstituted carbonyl compounds with aryl diamine leading to quinoxalines using molecular oxygen as oxidant. Tetrahedron, 2012, 68, 5258.

16. Chun Zhang, Xiaoyang Wang, Ning Jiao*, Copper-Catalyzed Aerobic Oxidative C–C Bond Cleavage of 1,3-Diaryl­diketones To Synthesize 1,2-Diketones, Synlett, 2014, 25, 1458.