马军安 博士

天津大学有机化学教授,博士生导师

办公及实验室:第3教学楼115

Tel: 0086-22-27402903

Fax: 0086-22-27403475

Email: majun_an68@tju.edu.cn

 

教育及科研经历  教学情况  研究方向  荣誉及奖励  课题组成员  国际合作  科研成果

 

教育及科研经历

1987, 91991, 8

1991, 91994, 6

1994, 71996, 8

1996, 91999, 6

1999, 72002, 11

2002, 122003,12

2004, 12005, 6

2008, 42008, 9

2005, 7至今

河南大学化学化工学院化学专业学习并获理学硕士学位

南开大学元素所有机化学专业学习并获理学硕士学位

广州百花香料股份有限公司研发部工作(助理研究员)

南开大学元素所精细有机及农药化学专业并获理学博士学位(导师黄润秋教授)

南开大学化学学院元素所工作(讲师、副教授)

法国国家科研中心(CNRS)精细化学研究所博士后(合作教授: Dominique Cahard

德国马谱 (MPI)煤炭化学研究所博士后(合作教授:Manfred T. Reetz

日本理化学研究所RIKENJSPS fellow)(合作教授:Mikiko Sodeoka

天津大学理学院化学系工作(教授)

 

教学情况

1承担大学本科生专业必修课《精细有机合成》

2、研究生专业必修课《高等有机合成》、《立体化学》及《化学前沿进展》

 

研究方向

1、手性化合物不对称合成研究:包括(1)新型手性催化剂设计合成;(2)催化不对称新反应及新合成方法研究;(3)具生物活性的手性化合物设计合成

2、有机氟化学工程化研究:包括(1)含氟有机功能化合物的设计、合成及反应研究;(218FPET成像探针及药物设计合成,主要用于肿瘤诊断;(3)天然产物及药物氟工程化修饰及活性筛选,主要用于创制新药物

 

荣誉及奖励

11997年度广东省新产品研发三等奖;

21998年度广州市科技进步二等奖;

32003年中国化工学会优秀论文奖;

42005年度入选教育部新世纪优秀人才;

52006年度入选天津市“131”创新型人才培养工程(第一层次)

62007年度获得天津市五一劳动奖章

72008年度入选国务院政府特贴专家

82008年度被评为天津市优秀留学回国人员

92010法国应用科学研究所(INSA)客座教授

102012年度国家杰出青年科学基金获得者

112012年度教育部宝钢优秀教师奖获得者

122013年获得Thieme Chemistry Journal Award国际期刊学术奖励

 

课题组成员

目前成员:

郑艳

副教授

Email:tjuzhengyan@tju.edu.cn

聂晶

副教授

Email:njtjuchem@gmail.com

杨真艳

zhenyanyang2000@163.com

王帅

wws86868@gmail.com

杨丽军

Yanglijunly@126.com

任楠

rennan6@126.com

郭冉

guoran900618@126.com

魏溢

weiyi@tju.edu.cn

陈振

chenzheng09@tju.edu.com

魏爱佳

weiaijia2012@126.com

易玉平

yyp890820@163.com

来博男

bonanlai@163.com

曾俊良

ZJL0900716@163.com

蔡爱杰

caj214214@163.com

 

 

 

毕业成员:

王琏

tonny19840224@yahoo.com.cn

华明清

huamq840710@163.com

张光武

gw_zhang@tju.edu.cn

朱宏伟

Zhw512@eyou.com

董科研

Dongkeyan1983@163.com

崔汉峰

cuihanfeng@126.com

李小娟

lovewavespo@gmail.com

刘昆

liukun1980@gmail.com

裴增楷

Peizengkai@163.com

郑东华

Zdh_63594213063@163.com

张宁

Zhangning3158@126.com

张晓玲(导师郑艳)

Zhangxiaoling886@126.com

马海

mahai821124@163.com

孟玮

thegrimreaperlfc@gmail.com

李峰

Lifeng198517@gmail.com

王腾

wanton1984@sina.com

张发光

cszfg0415@163.com

传乐

zhuchuanle618@gmail.com

刘天林

hollandtian@gmail.com

吴俊威

tjdx2009375@163.com

祝小艳

459546106@qq.com

孟文婷(导师郑艳)

Ting_126@126.com

刘翠波(导师郑艳)

chemliiucuibo@163.com

熊恒英(导师郑艳)

xionghengying@163.com

袁海娜

672012875@qq.com

孙龙(导师郑艳)

sunlong1988521@126.com

张克枫

kfzhang0812@163.com

张恒霞

zhanghengxia1988@163.com

唐晓冬

xiaodong2007127130@126.com

 

 

国际合作

目前与欧、美、日三个有机化学实验室建立国际合作关系:

1)法国国家科学研究中心(CNRS)精细化学研究所(IRCOF)及鲁昂大学:

Prf. Dr. Dominique Cahard

UMR 6014 CNRS, laboratoire COBRA de l'IRCOF, Université et INSA de Rouen,

Rue Tesniere, F-76130 Mont Saint Aignan, France

Email: Dominique.Cahard@univ-rouen.fr

(2)日本理化学研究所(RIKEN)

Prof. Dr. Mikiko Sodeoka

Synthetic Organic Chemistry Lab

RIKEN (The Institute of Physical and Chemical Research)

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

E-mail: sodeoka@riken.jp

3)美国德州大学(圣安东尼奥)

Prof. Dr. John Conggui Zhao

Department of Chemistry,

University of Texas at San Antonio,

Email: cong.zhao@utsa.edu

4)美国南加州大学

Prof. Dr. Kai Chen

Molecular Imaging Center & Keck School of Medicine,

University of Southern California

Email: chenkai@usc.edu

 

科研成果

目前发表学术论文90多篇,论文被他引用次数达二千二百余次。申请专利12项(其中五项已获授权),参编书籍5部,作为项目负责人,先后承担和完成国家、省部级科研目项十多项。参见国际国内学术会议,被邀请做大会及口头报告近三十次。

近年发表期刊论文

1.                  Hua Cai, Jing Nie, Yan Zheng, and Jun-An Ma*, Lithium Binaphtholate-Catalyzed Enantioselective Enyne Addition to Ketones: Access to Enynylated Tertiary Alcohols, J. Org. Chem. 2014, 79, 5484–5493.

2.                  Fa-Guang Zhang, Yi Wei, Yu-Ping Yi, Jing Nie, and Jun-An Ma*, Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3Substituted Pyrazolines and Pyrazoles, Org. Lett. 2014, 16, 3122–3125.

3.                  Jun-An Ma* and Shen Li, Catalytic fluorination of unactivated C(sp3)–H bonds, Org. Chem. Front. 2014, 1, 712715.

4.                  Heng-Xia Zhang, Jing Nie, Hua Cai, and Jun-An Ma*, Cyclic Aldimines as Superior Electrophiles for Cu-Catalyzed Decarboxylative Mannich Reaction of β-Ketoacids with a Broad Scope and High Enantioselectivity, Org. Lett. 2014, 16, 2542–2545.

5.                  Li-Jun Yang, Shen Li, Shuai Wang, Jing Nie, and Jun-An Ma*, Nucleophilic Lewis Base Dependent Addition Reactions of Allenoates with Trifluoromethylated Cyclic Ketimines. J. Org. Chem. 2014, 79, 35473558.

6.                  Shuai Wang, Jing Nie, Yan Zheng, and Jun-An Ma*, A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes, Org. Lett. 2014, 16, 16061609.

7.                  Ke-Feng Zhang, Jing Nie, Ran Guo, Yang Zheng, Jun-An Ma*, Chiral Phosphoric Acid-Catalyzed Asymmetric Aza-Friedel–Crafts Reaction of Indoles with Cyclic N-Acylketimines: Enantioselective Synthesis of Trifluoromethyl-dihydroquinazolines, Adv. Synth. Catal. 2013, 355, 3497–3502.

8.                  Hai-Na Yuan, Shen Li, Jing Nie, Yan Zheng, and Jun-An Ma, Highly Enantioselective Decarboxylative Mannich Reaction of Malonic Acid Half Oxyesters with Cyclic Trifluoromethyl Ketimines: Synthesis of β-Amino Esters and Anti-HIV Drug DPC 083, Chem. Eur. J. 2013, 19, 15856–15860.

9.                  Li-Jun Yang, Shuai Wang, Jing Nie, Shen Li, and Jun-An Ma*, Bisphosphine-Triggered One-Pot Sequential [3 + 2]/[3+ 2] Annulation of Allenoates with Cyclic Ketimines, Org. Lett. 2013, 15, 5214-5217.

10.              Feng Li, Jing Nie, Long Sun, Yan Zheng, Jun-An Ma*,Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles”, Angew. Chem. Int. Ed. 2013, 52, 6375–6378.

11.              Hai-Na Yuan, Shuai Wang, Jing Nie, Wei Meng, Qingwei Yao, and Jun-An Ma*, Hydrogen-Bond-Directed Enantioselective Decarboxylative Mannich Reaction of β-Ketoacids with Ketimines: Application to the Synthesis of Anti-HIV Drug DPC 083, Angew. Chem. Int. Ed. 2013, 52, 38693873.

12.              Wen-Ting Meng, Yan Zheng, Jing Nie, Heng-Ying Xiong, Jun-An Ma, Organocatalytic Asymmetric One-pot Sequential Conjugate Addition/ Dearomative-Fluorination: Synthesis of Chiral Fluorinated Isoxazol-5(4H)-ones, J. Org. Chem. 2013, 78, 559567.

13.              Tian-Lin Liu, Heng-Xia Zhang, Yan Zheng, Qingwei Yao, Jun-An MaCatalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines, Chem. Commun. 2012, 48, 12234–12236.

14.              Feng Li, Long Sun, Yuou Teng, Peng Yu, John Cong-Gui Zhao, Jun-An Ma, Highly Diastereo- and Enantioselective Organocatalytic One-Pot Sequential 1,4-Addition/Dearomative-Fluorination Transformation, Chem. Eur. J. 2012, 18, 14255–14260.

15.              Fa-Guang Zhang, Xiao-Yan Zhu, Shen Li, Jing Nie, Jun-An Ma*, Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083, Chem. Commun. 2012, 48, 11552–11554.

16.              Wei Meng, Hai-Tao Zhao, Jing Nie, Yan Zheng, Aiping Fu, Jun-An Ma*, “Allenoate-derived 1,5-, 1,7-, and 1,9-zwitterions as highly versatile coupling partners for phosphine-triggered cycloaddition reactions” Chem. Sci. 2012, 3, 30533057.

17.              Cui-Bo Liu, Wei Meng, Feng Li, Shuai Wang, Jing Nie, Jun-An Ma*, “A Facile Parallel Synthesis of Trifluoroethyl-Substituted Alkynes”, Angew. Chem. Int. Ed. 2012, 51, 6227–6230.

18.              Jing Nie, Ming-Qing Hua, Heng-Ying Xiong, Yan Zheng, Jun-An Ma*, Asymmetric Phase-Transfer Catalyzed Conjugate Addition of Glycine Imine to Exocyclic α,β-Unsaturated Ketones: Construction of Polycyclic Imines Containing Three Stereocenters, J. Org. Chem. 2012, 77(9), 42094216.

19.              Yan Zheng, Heng-Ying Xiong, Jing Nie, Ming-Qing Hua, Jun-An Ma*, Biomimetic Catalytic Enantioselective Decarboxylative Aldol Reaction of β-Ketoacids with Trifluoromethyl Ketones, Chem. Commun. 2012, 48, 43084310.

20.              Fa-Guang Zhang, Hai Ma, Jing Nie, Yan Zheng, Qingzhi Gao, Jun-An Ma*, Enantioselective Diynylation of Cyclic N-Acyl Ketimines: Access to Chiral Trifluoromethylated Tertiary Carbinamines, Adv. Synth. Catal. 2012, 354, 1422–1428.

21.              Feng Li, Jing Nie, Jun-Wei Wu, Yan Zheng, Jun-An Ma*, Stereoselective Synthesis of Fluorinated 2,3-Dihydroquinolin-4(1H)-2-ones via a One-Pot Multistep Transformation, J. Org. Chem. 2012, 77, 23982406.

22.              Tian-Lin Liu, Hai Ma, Fa-Guang Zhang, Yan Zheng, Jing Nie, Jun-An Ma*, Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols, Chem. Commun. 2011, 47, 12873–12875.

23.              Lian Wang, Wei Meng, Chuan-Le Zhu, Yan Zheng, Jing Nie, Jun-An Ma*, The Long-Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo- and Enantioselectivity of the Tandem 1,4-Addition/Fluorination, Angew. Chem. Int. Ed. 2011, 50, 94429446.

24.              Chuan-Le Zhu, Fa-Guang Zhang, Wei Meng, Jing Nie, Dominique Cahard, Jun-An Ma*, Enantioselective Base-Free Electrophilic Amination of Benzofuran-2(3H)-ones: Catalysis by Binol-Derived P-Spiro Quaternary Phosphonium Salts, Angew. Chem. Int. Ed. 2011, 50, 5869–5872.

25.              Guang-Wu Zhang, Wei Meng, Hai Ma, Jing Nie, Wen-Qin Zhang, Jun-An Ma*, “Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects, Observation and Practical Implications of Zinc-to-Titanium Transmetalation”, Angew. Chem. Int. Ed. 2011, 50, 35383542.

26.              Ming-Qing Hua, Lian Wang, Han-Feng Cui, Jing Nie, Xiao-Ling Zhang, Jun-An Ma*, A powerful synergistic effect for highly efficient diastereo- and enantioselective phase-transfer catalyzed conjugate additions, Chem. Commun. 2011, 47, 16311633.

27.              Jing Nie, Hong-Chao Guo, Dominique Cahard,  Jun-An Ma*, Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates, Chem. Rev. 2011, 111, 455529.

28.              Ming-Qing Hua, Han-Feng Cui, Lian Wang, Jing Nie, Jun-An Ma*, Reversal of Enantioselectivity by Tuning the Conformational Flexibility of Phase-Transfer Catalysts, Angew. Chem. Int. Ed. 2010, 49, 27722776.

29.              Hai Ma, Kun Liu, Fa-Guang Zhang, Chuan-Le Zhu, Jing Nie, Jun-An Ma*, Chiral Bifunctional Thiourea-Catalyzed Enantioselective Michael Addition of Ketones to Nitrodienes, J. Org. Chem. 2010, 75, 1402–1409.

30.              Guang-Wu Zhang, Dong-Hua Zheng, Jing Nie, Teng Wang, Jun-An Ma*, Brønsted Acid-catalyzed Efficient Strecker Reaction of Ketones, Amines and Trimethylsilyl Cyanide, Org. Biomol. Chem. 2010, 8, 13991405.

31.              J. Nie, G.-W. Zhang, L. Wang, A. Fu, Y. Zheng, Jun-An Ma*, A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Brøsted acid-catalyzed direct arylation of trifluoromethyl ketones, Chem. Commun., 2009, 2356–2358.

32.              Jun-An Ma, Dominique Cahard, Update: Asymmetric Fluorination, Trifluoromethylation and Perfluoroalkylation, Chem. Rev. 2008, 108(9), PR143.

33.              Guang-Wu Zhang, Lian Wang, Jing Nie, Jun-An Ma*, Chiral Brønsted Acid-Mediated Enantioselective Organocatalytic Three-component Reaction for the Construction of Trifluoromethyl-containing Molecules, Adv. Synth. Catal. 2008, 350, 1457–1463.

34.              Jing Nie, Hong-Wei Zhu, Han-Feng Cui, Ming-Qing Hua, Jun-An Ma*, Catalytic Stereoselective Synthesis of Highly Substituted Indanones via Tandem Nazarov Cyclization and Electrophilic Fluorination Trapping, Org. Lett. 2007, 9, 3053–3056.

35.              Han-Feng Cui, Ke-Yan Dong, Guang-Wu Zhang, Lian Wang, Jun-An Ma*, Stereoselective Construction of Fluorinated Indanone Derivatives via a Triple Cascade Lewis Acid-Catalyzed Reaction, Chem. Commun. 2007, 2284–2286.

36.              Kun Liu, Han-Feng Cui, Jing Nie, Ke-Yan Dong, Xiao-Juan Li, Jun-An Ma*, Highly Enantioselective Michael Addition of Aromatic Ketones to Nitroolefins Promoted by Chiral Bifunctional Primary Amine-thiourea Catalysts Based on Saccharides, Org. Lett. 2007, 9, 923–925.

37.              Jun-An Ma*, Catalytic Asymmetric Synthesis of α- and β-Amino Phosphonic Acid Derivatives, Chem. Soc. Rev. 2006, 35, 630–636.

38.              Hong-Chao Guo, Jun-An Ma*, Catalytic asymmetric tandem transformations triggered by conjugate addition, Angew. Chem. Int. Chem. 2006, 45, 354–366.

39.              M. T. Reetz*, Jun-An Ma, R. Goddard, BINOL-derived monodentate phosphites and phosphoramidites with P-sterogenic centers: novel ligands for transition metal catalysis, Angew. Chem. Int. Ed. 2005, 44, 412–415.

40.              Jun-An Ma, Dominique Cahard, Asymmetric Fluorination, Trifluoromethylation and Perfluoroalkylation, Chem. Rev. 2004, 104 (12), 61196146.

41.              Jun-An Ma, Dominique Cahard, Towards perfect catalytic asymmetric synthesis: dual activation for the electrophiles and the nucleophiles, Angew. Chem. Int. Ed. 2004, 43, 4566–4583.

42.              Jun-An Ma*, Recent Developments in Catalytic Asymmetric Synthesis of a- and b-Amino Acids, Angew. Chem. Int. Ed. 2003, 42, 4290–4299.